A case of nodular regenerative hyperplasia in a patient who had been taking didanosine
نویسندگان
چکیده
Purpose of study It is widely recognised that liver disease causes significant morbidity and mortality in HIV positive patients. Many patients are co-infected with hepatitis B and C, have increased alcohol intake or are on hepatotoxic medication e.g. nevirapine, which can cause acute hepatitis or liver cirrhosis. Nodular regenerative hyperplasia (NRH) is characterised by the presence of diffuse, small regenerative nodules in the absence of significant cirrhosis. Prior use of didanosine is associated with NRH. It leads to portal hypertension, oesophageal varices and subsequent gastrointestinal haemorrhage.
منابع مشابه
Nodular regenerative hyperplasia of the liver associated with didanosine persists for years even after its interruption.
The authors describe an HIV-positive patient with nodular regenerative hyperplasia of the liver with non-cirrhotic portal hypertension. Despite stopping the culprit drug, didanosine, the radiologic changes persisted for years. When evaluating liver pathologies, antiretroviral drugs must be included in the differential diagnosis, even when they have been stopped years ago.
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